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[4] [5] Additional contributing factors include: Sleep disturbances and night sweats disrupting metabolic regulation Reduced physical activity due to fatigue or joint discomfort Psychological factors including stress, mood changes, and emotional eating Changes in insulin sensitivity Weight changes during the menopausal transition vary considerably between individuals
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Sleep deprivation and chronic stress can disrupt the hormones that regulate your metabolism and appetite, making it much harder to lose weight
The mechanism of action of GLP-1 agonists involves binding to GLP-1 receptors on pancreatic beta cells, which stimulates glucose-dependent insulin secretion
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